KAKEN — Research Projects | Researcher Number: 10243502

1. persister癌細胞と腫瘍微小環境の双方を標的とした革新的腫瘍免疫療法の開発

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Review Section	Basic Section 53030:Respiratory medicine-related
Research Institution	Okayama University
Principal Investigator	大橋圭明岡山大学, 大学病院, 准教授
Project Period (FY)	2022-04-01 – 2025-03-31Granted
Keywords	肺癌 / EGFR変異 / 腫瘍免疫 / 非小細胞肺癌 / persister癌細胞 / CD8陽性T細胞 / 抗腫瘍免疫 / EGFR肺癌 / EGFR－TKI / 腫瘍微小環境 / 腫瘍免疫療法
Outline of Research at the Start	EGFR変異を有する肺癌は、日本人の非喫煙者に発生する肺癌の半数以上を占める重要な疾患だが、EGFR阻害薬では治すことが困難である。EGFR阻害薬への抵抗性について試験管レベルの実験では免疫応答の評価が困難であった。本研究では、独自にEgfr遺伝子改変肺癌マウスを樹立し、マウス2型肺胞上皮を起源とす ...
Outline of Annual Research Achievements	上皮成長因子受容体変異を有する肺癌（EGFR肺癌）は、日本人の非喫煙者に発生する肺癌の半数以上を占める重要な疾患である。EGFRチロシンキナーゼ阻害薬（TKI）は、EGFR肺癌に一過性に奏効するが、耐性化し治癒には至らない。EGFR-TKI投与後に残存するpersister癌細胞と呼ばれる細胞集団が ...
Current Status of Research Progress	2: Research has progressed on the whole more than it was originally planned.

Research Products of this project	Int'l Joint Research (1 results) Journal Article (6 results, of which Peer Reviewed: 1 results) Presentation (4 results)

2. Establishment of a mouse model of Oct4-positive lung cancer stem cells and development of innovative therapies to eradicate cancer stem cells

Research Project

Research Category	Grant-in-Aid for Challenging Research (Exploratory)
Review Section	Medium-sized Section 53:Organ-based internal medicine and related fields
Research Institution	Okayama University
Principal Investigator	Ohashi Kadoaki 岡山大学, 大学病院, 准教授
Project Period (FY)	2022-06-30 – 2024-03-31Completed
Keywords	非小細胞癌 / 癌幹細胞 / Oct4 / 非小細胞肺癌 / EGFR変異 / ２型肺胞上皮細胞 / 肺癌 / Oct４ / 2型肺胞上皮細胞 / 腫瘍微小環境
Outline of Research at the Start	上皮成長因子受容体（EGFR）遺伝子変異を有する肺癌（EGFR肺癌）は、非喫煙者に発生する肺腺癌の半数以上を占めるが、薬物療法で根治できない。多分化能をもつ癌幹細胞（cancer stem cells：CSCs)が根治の障壁の一因とされるが、CSCsのin vivoモデルは確立していない。CSCsの ...
Outline of Final Research Achievements	Cancer stem cells (CSCs) have attracted attention as a cause of lung cancer that cannot be cured by drug therapy, but their pathogenesis is not yet un ...

Research Products of this project	Journal Article (6 results, of which Peer Reviewed: 4 results, Open Access: 2 results) Presentation (4 results)

3. Development of a curative treatment strategy for lung cancer using the persister cancer cell mouse model.

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Review Section	Basic Section 53030:Respiratory medicine-related
Research Institution	Okayama University
Principal Investigator	Ohashi Kadoaki 岡山大学, 大学病院, 研究准教授
Project Period (FY)	2019-04-01 – 2022-03-31Completed
Keywords	非小細胞肺癌 / EGFR変異 / 腫瘍免疫 / PD-1 / VEGR2 / 肺癌 / 非小細胞癌 / persister / persisterがん細胞 / 遺伝子改変マウス
Outline of Research at the Start	EGFR変異を伴う肺癌は、日本人の非喫煙者に発生する肺癌の半数以上を占める重要な疾患である。EGFRチロシンキナーゼ阻害薬（TKI）は、高い効果を示すが、完全寛解、根治しないことが未解決の課題である。「persister」がん細胞（しつこく生き残る耐性細胞）と呼ばれる細胞集団が、完全寛解、根治に向け ...
Outline of Final Research Achievements	EGFR tyrosine kinase inhibitors (TKIs) transiently inhibit but can not eradicate lung cancer with EGFR mutations . In this study, we independently es ...

Research Products of this project	Int'l Joint Research (2 results) Journal Article (16 results, of which Int'l Joint Research: 3 results, Peer Reviewed: 16 results, Open Access: 10 results) Presentation (8 results, of which Int'l Joint Research: 6 results)

4. Development of innovative immunotherapy for lung cancer using tumor immune-activating gene REIC

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Review Section	Basic Section 53030:Respiratory medicine-related
Research Institution	Okayama University
Principal Investigator	Katsuyuki Kiura 岡山大学, 大学病院, 教授
Project Period (FY)	2019-04-01 – 2023-03-31Completed
Keywords	非小細胞肺癌 / EGFR変異 / REIC / 抗腫瘍免疫療法 / PD-1 / 肺腺癌 / 腫瘍免疫 / 腫瘍免疫療法 / 肺癌 / ＥＧＦＲ変異 / ウィルスベクター / 遺伝子治療 / 呼吸器の腫瘍 / Ad- SGE-REIC
Outline of Research at the Start	EGFR 変異を有する肺癌は、EGFRチロシンキナーゼ阻害薬（TKI）に奏効するが、治癒することはない。免疫チェックポイント阻害薬（ICI）の効果が乏しいことも、未解決の重要課題である。REIC遺伝子はがん細胞選択的に免疫原性細胞死を誘導し、同時に局所および全身的な腫瘍免疫の活性化を誘導する。
Outline of Final Research Achievements	The development of effective anti-tumor immunotherapy for EGFR-mutant lung cancer remains a crucial unresolved challenge. The REIC gene selectively in ...

Research Products of this project	Journal Article (16 results, of which Peer Reviewed: 16 results, Open Access: 4 results) Presentation (11 results, of which Int'l Joint Research: 4 results) Patent(Industrial Property Rights) (3 results, of which Overseas: 2 results)

5. Comprehensive analysis of druggable tyrosine kinase in idiopathic interstitial pneumonia

Research Project

Research Category	Grant-in-Aid for Challenging Exploratory Research
Research Field	Respiratory organ internal medicine
Research Institution	Okayama University
Principal Investigator	Kiura Katsuyuiki 岡山大学, 大学病院, 教授
Project Period (FY)	2016-04-01 – 2018-03-31Completed
Keywords	肺線維症 / 特発性肺線維症 / 次世代シーケンサー / Kinase遺伝子発現解析 / レーザーマイクロダイセクション / 臨床呼吸器学
Outline of Final Research Achievements	We performed comprehensive analysis in plumonary fibrosis to develop precision medicine.　We obtained 13 samples from 5 patients. 6 samples were from b ...

Research Products of this project	Journal Article (19 results, of which Int'l Joint Research: 2 results, Peer Reviewed: 19 results) Presentation (5 results, of which Int'l Joint Research: 4 results)

6. Next generation lung cancer mice model for conquering cancer stem

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Respiratory organ internal medicine
Research Institution	Okayama University
Principal Investigator	Kiura Katsuyuki 岡山大学, 大学病院, 教授
Project Period (FY)	2015-04-01 – 2019-03-31Completed
Keywords	肺癌 / EGFR変異 / 癌幹細胞 / 遺伝子改変マウスモデル / 非小細胞癌 / 肺癌幹細胞 / 臨床呼吸器学 / 呼吸器の腫瘍 / EGFR肺癌 / 内科 / 非小細胞肺癌
Outline of Final Research Achievements	NSCLC harboring EGFR mutations represents one of the most critical subgroups of the cancer in clinical practice.EGFR tyrosine-kinase inhibitors (EGFR- ...

Research Products of this project	Journal Article (32 results, of which Int'l Joint Research: 2 results, Peer Reviewed: 31 results, Open Access: 4 results, Acknowledgement Compliant: 1 results) Presentation (13 results, of which Int'l Joint Research: 11 results)

7. Potential influence of interleukin-6 on the therapeutic effect of gefitinib in patients with advanced non-small cell lung cancer harbouring EGFR mutations

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Tumor therapeutics
Research Institution	Okayama University
Principal Investigator	Hotta Katsuyuki 岡山大学, 大学病院, 教授
Project Period (FY)	2014-04-01 – 2018-03-31Completed
Keywords	肺癌 / EGFR / IL-6 / チロシンキナーゼ阻害薬 / EGFR遺伝子変異陽性非小細胞肺がん / EGFR-TKI / インターロイキン6（IL-6）
Outline of Final Research Achievements	In our study, in 52 patients with EGFR-mutat lung cancer who received gefitinib, EGFR tyrosine kinase inhibitor (TKI), the high IL-6 expression group, ...

Research Products of this project	Journal Article (1 results, of which Peer Reviewed: 1 results) Presentation (1 results, of which Int'l Joint Research: 1 results)

8. Basic study on combined modality therapy for advanced lung cancer harboring activated EGFR gene mutation

Research Project

Research Category	Grant-in-Aid for Challenging Exploratory Research
Research Field	Respiratory organ internal medicine
Research Institution	Okayama University
Principal Investigator	KIURA Katsuyuki 岡山大学, 大学病院, 教授
Project Period (FY)	2013-04-01 – 2015-03-31Completed
Keywords	上皮成長因子受容体 / PD-L1 / EGFR遺伝子変異 / Egfr遺伝子改変マウス / 免疫染色 / EGFR阻害薬 / 手術検体 / 相関 / EGFR / EGFR遺伝子改変マウス / 抗PD-１抗体 / 抗PD-L1抗体 / EGFR遺伝子変異陽性肺癌 / PNA LNA PCR-Clamp法 / PD-1抗体 / PD-L1抗体 / gefetinib / everolimus / afatinib / vandetanib
Outline of Final Research Achievements	It has been suggested that expression of epidermal growth factor receptor (EGFR) gene mutation induces PD-L1 on the tumor cells, and that PD-L1 expres ...

Research Products of this project	Journal Article (8 results, of which Peer Reviewed: 7 results) Book (1 results)

9. Identification of stem cells from oncogenic mouse lungs by epithelial growth factor receptor gene mutation

Research Project

Research Category	Grant-in-Aid for Challenging Exploratory Research
Research Field	Respiratory organ internal medicine
Research Institution	Okayama University
Principal Investigator	SATO AKIKO 岡山大学, 医歯薬学総合研究科, 助教
Project Period (FY)	2012-04-01 – 2017-03-31Completed
Keywords	BASCs / EGFR遺伝子変異改変マウス / 器官培養 / EGFR遺伝子改変マウス / マウスEGFR遺伝子改変マウス / EGFR遺伝子変異 / EGFRチロシンリン酸化酵素阻害剤 / マウスEgfr遺伝子改変マウス / EGFRチロシンリン酸化酵素阻害薬 / 胎仔の器官培養 / 肺がん幹細胞
Outline of Final Research Achievements	We used fetuses born by genetically modified mouse (♂) and wild type C57BL / 6 mouse (♀) which introduced EGFR gene mutation (mouse EGFRExon 19 delE 7 ...

Research Products of this project	Journal Article (2 results, of which Peer Reviewed: 2 results, Open Access: 2 results) Presentation (1 results)

10. Effects of molecular-targeted drugs on nonsmoking-related lung cancer models

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Respiratory organ internal medicine
Research Institution	Kawasaki Medical School
Principal Investigator	TAKIGAWA Nagio 川崎医科大学, 医学部, 教授
Project Period (FY)	2012-04-01 – 2015-03-31Completed
Keywords	EGFR / mTOR / JAK2 / STAT3 / 肺癌 / 薬剤耐性 / 遺伝子改変マウス / 血管新生
Outline of Final Research Achievements	EGFR mutations are more frequently observed in non-smokers and adenocarcinoma patients. The majority of EGFR mutant lung cancers initially sensitive t ...

Research Products of this project	Journal Article (7 results, of which Peer Reviewed: 7 results, Acknowledgement Compliant: 2 results, Open Access: 1 results) Presentation (4 results)

11. A basic studyon malignant mesothelioma pathogenesis by internal radiation exposure of radium contained in the iron-containing protein

Research Project

Research Category	Grant-in-Aid for Challenging Exploratory Research
Research Field	Respiratory organ internal medicine
Research Institution	Okayama University
Principal Investigator	KIURA Katsuyuki 岡山大学, 岡山大学病院, 教授
Project Period (FY)	2011 – 2012Completed
Keywords	非閉塞性肺疾患癌 / 悪性中皮腫 / ラジウム / 生体内被曝 / 鉄 / 発癌 / プリミティブマントル正規化微量原素パターン / ラット / 含鉄蛋白 / 体内被曝 / (1)含鉄蛋白質
Research Abstract	Ten healthy male Slc: Wistar rats were repeatedly injected (i.p.) with a chelating agent and iron. Five of 10 rats showed a malignant peritoneal mesot ...

Research Products of this project	Journal Article (6 results, of which Peer Reviewed: 6 results)

12. Basic and clinical study of EGFR gene mutation-positive lung cancer using a genetically modified mouse

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Respiratory organ internal medicine
Research Institution	Okayama University
Principal Investigator	KIURA Katsuyuki 岡山大学, 大学病院, 教授
Project Period (FY)	2011-04-01 – 2015-03-31Completed
Keywords	EGFR遺伝子改変マウス / afatinib / everolimus (mTOR阻害薬), / JAK-1/2 inhibitors / cetuximab / bevacizumab / Ogg1ホモノックアウトマウス / NNK / EGFR / everolims / AZD1480 / gefitinib / 用量依存性 / 遺伝子改変マウス / ｍTOR阻害薬 / everolimus / JAK1/2阻害薬 / BIBW2552 / mTOR阻害薬
Outline of Final Research Achievements	① Using the EGFR genetically modified mice, afatinib (irreversible TKI), everolimus (mTOR inhibitor), and AZD1480 (JAK-1/2 inhibitors) revealed an ant ...

Research Products of this project	Journal Article (23 results, of which Peer Reviewed: 23 results, Acknowledgement Compliant: 5 results) Presentation (15 results) Book (3 results)

13. Radiofrequency ablation for pulmonary aspergilloma

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Radiation science
Research Institution	Okayama University
Principal Investigator	HIRAKI Takao 岡山大学, 岡山大学病院, 講師
Project Period (FY)	2010 – 2012Completed
Keywords	ラジオ波焼灼療法 / アスペルギローマ / ラジオ波治療 / 真菌症 / 肺アスペルギローマ
Research Abstract	Radiofrequency ablation was performed for pulmonary aspergilloma. The procedure was safely done without any adverse events. Serial follow-up CT scan u ...

Research Products of this project	Journal Article (11 results, of which Peer Reviewed: 11 results) Presentation (9 results) Remarks (2 results)

14. 上皮成長因子受容体遺伝子変異陽性肺癌の根治治療開発を目指した動物実験モデルの樹立

Research Project

Research Category	Grant-in-Aid for Challenging Exploratory Research
Research Field	Respiratory organ internal medicine
Research Institution	Okayama University
Principal Investigator	木浦勝行岡山大学, 大学院・医歯薬学総合研究科, 准教授
Project Period (FY)	2009 – 2010Completed
Keywords	上皮成長因子受容体 / 上皮成長因子受容遺伝子異 / 遺伝子改変マウス / ドセタキセル / ジェムサイタビン / ゲフィチニブ / 動物実験モデル / 肺癌 / EGFR / L858R / ヴィノレルビン
Research Abstract	申請者らはヒト上皮成長因子受容体(EGFR)遺伝子変異を恒常的にマウス肺に発現させるため,2型肺胞上皮で特異的に作動するSPCプロモーターを使用し,二系統のEGFR遺伝子改変マウス(ヒトEGFR exon 21 L858R,マウスEGFR exon 19 del E748-A752)を樹立し,これら ...

Research Products of this project	Journal Article (6 results, of which Peer Reviewed: 5 results) Presentation (2 results)

15. Mechanism of progression from bronchioloalveolar carcinoma to invasive adenocarcinoma

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Respiratory organ internal medicine
Research Institution	Kawasaki Medical School (2011) Okayama University (2009-2010)
Principal Investigator	TAKIGAWA Nagio 川崎医科大学, 医学部, 教授
Project Period (FY)	2009 – 2011Completed
Keywords	肺癌 / 発癌 / EGFR / 肺腺癌 / 遺伝子変異
Research Abstract	Bronchioloalveolar carcinoma(BAC) pattern is often seen at the margin of invasive adenocarcinomas. We investigated EGFR signaling abnormalities involv ...

Research Products of this project	Journal Article (6 results, of which Peer Reviewed: 6 results) Presentation (10 results)

16. Chemoprevention of Lung Cancer using Epidermal Growth Factor Receptor Transgenic Mice

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Respiratory organ internal medicine
Research Institution	Okayama University
Principal Investigator	KIURA Katsuyuki Okayama University
Project Period (FY)	2007 – 2008Completed
Keywords	肺癌 / 腺癌 / 非喫煙者 / 化学予防 / 遺伝子改変マウス / 上皮成長因子受容体 / ゲフィチニブ / バンデタニブ / 肺腺癌 / 血管内皮細胞成長因子受容体 / 分子標的化学予防 / ZD6474 / 非喫煙 / EGFR / SP-C
Research Abstract	肺癌の粗死亡数は増加しているが、喫煙率低下に伴い年齢調整死亡率は低下傾向にある。肺癌患者の男性30%、女性70%は非喫煙者である。非喫煙者肺癌の病因探求およびその予防の研究目的で、上皮成長因子受容体(EGFR)遺伝子改変マウスを作製し、非喫煙関連肺癌マウスモデルを樹立した。ヒトEGFR遺伝子改変マウ ...

Research Products of this project	Journal Article (9 results, of which Peer Reviewed: 9 results) Presentation (4 results) Book (1 results)

17. Early detection of lung cancer using aberrant promoter hypermethylation in serum DNA from patients with silicosis

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Respiratory organ internal medicine
Research Institution	Okayama University
Principal Investigator	TABATA Masahiro Okayama University
Project Period (FY)	2006 – 2008Completed
Keywords	癌 / 肺線維症 / 肺癌 / 塵肺 / 早期診断 / 血清遊離DNA / メチル化DNA / (5)メチル化DNA
Research Abstract	塵肺に合併する肺癌は業務上疾病に認定され種々の対策が講じられているが、従来の画像診断と喀痰細胞診による検診のみでは確実な早期診断が困難なことから塵肺に合併した肺癌患者の予後はきわめて不良である。このような状況の下、本研究では肺癌を合併していない塵肺患者に比して、塵肺肺癌患者で末梢血中に認められる遊離 ...

Research Products of this project	Journal Article (2 results, of which Peer Reviewed: 2 results) Presentation (4 results) Remarks (1 results)

18. Mechanism of carcinogenesis from pulmonary atypical adenomatous hyperplasia to adenocarcinoma

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Respiratory organ internal medicine
Research Institution	Okayama University
Principal Investigator	TAKIGAWA Nagio Okayama University
Project Period (FY)	2006 – 2008Completed
Keywords	肺癌 / 発癌 / 遺伝子変異 / 肺腺癌 / 重複癌
Research Abstract	上皮成長因子受容体(EGFR)遺伝子変異は肺腺癌の前癌病変である異型腺腫様過形成(AAH)においても肺腺癌においても同程度に認められた。AAHおよび腺癌の多発病変を有する症例の解析により、同一患者においても病変ごとにEGFR遺伝子変異のパターンが異なっていることが多く、変異はランダムに生じていると考 ...

Research Products of this project	Journal Article (11 results, of which Peer Reviewed: 4 results) Presentation (5 results) Book (2 results)

19. Chemoprevention of second primary cancer in the patients with lung cancer

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Respiratory organ internal medicine
Research Institution	Okayama University
Principal Investigator	KIURA Katsuyuki Okayama University, Okayama Graduate School of Medicine, Dentistry and Pharmaceutica Sciences, Associate Professor
Project Period (FY)	2004 – 2006Completed
Keywords	AKT / MAPK / A / J mouse / NNK / cisplatin / ras / lung cancer / second malignancy
Research Abstract	The risks of secondary lung cancer in patients with early stage non-small and small cell lung cancers are estimated to be 1-2% and 2-10% per patient p ...

Research Products of this project	Journal Article (18 results)

20. NK細胞白血病/リンパ腫の増殖機序と増殖抑制に関する研究

Research Project

Research Category	Grant-in-Aid for Exploratory Research
Research Field	Hematology
Research Institution	Kyushu University (2001) Okayama University (2000)
Principal Investigator	原田実根九州大学, 大学院・医学研究院, 教授
Project Period (FY)	2000 – 2001Completed
Keywords	NK細胞リンパ腫 / 鼻腔原発 / エプスタイン・バーウィルス(EBV) / latent membrane protein1 / アポトーシス / 薬剤耐性 / P糖蛋白 / NKリンパ種 / Epstein-Barr virus(EBV) / NK細胞 / LMP-1 / Bcl-2
Research Abstract	NK細胞白血病/リンパ腫の増殖機序と増殖抑制を検討するため、まず鼻腔原発NK細胞リンパ腫の白血病化症例から細胞株(NK-YS)を樹立した。本細胞株は形態的には大顆粒状リンパ球で表現型はCD2^+、CD3^-、CD5^+、CD7^+、CD16^-、CD56^+、CD57^-であり、EBウイルス(EBV ...

Research Products of this project	Publications (12 results)

Project Period (Start Year [FY])

1. persister癌細胞と腫瘍微小環境の双方を標的とした革新的腫瘍免疫療法の開発 Research Project

大橋 圭明 岡山大学, 大学病院, 准教授

2. Establishment of a mouse model of Oct4-positive lung cancer stem cells and development of innovative therapies to eradicate cancer stem cells Research Project

Ohashi Kadoaki 岡山大学, 大学病院, 准教授

3. Development of a curative treatment strategy for lung cancer using the persister cancer cell mouse model. Research Project

Ohashi Kadoaki 岡山大学, 大学病院, 研究准教授

4. Development of innovative immunotherapy for lung cancer using tumor immune-activating gene REIC Research Project

Katsuyuki Kiura 岡山大学, 大学病院, 教授

5. Comprehensive analysis of druggable tyrosine kinase in idiopathic interstitial pneumonia Research Project

Kiura Katsuyuiki 岡山大学, 大学病院, 教授

6. Next generation lung cancer mice model for conquering cancer stem Research Project

Kiura Katsuyuki 岡山大学, 大学病院, 教授

7. Potential influence of interleukin-6 on the therapeutic effect of gefitinib in patients with advanced non-small cell lung cancer harbouring EGFR mutations Research Project

Hotta Katsuyuki 岡山大学, 大学病院, 教授

8. Basic study on combined modality therapy for advanced lung cancer harboring activated EGFR gene mutation Research Project

KIURA Katsuyuki 岡山大学, 大学病院, 教授

9. Identification of stem cells from oncogenic mouse lungs by epithelial growth factor receptor gene mutation Research Project

SATO AKIKO 岡山大学, 医歯薬学総合研究科, 助教

10. Effects of molecular-targeted drugs on nonsmoking-related lung cancer models Research Project

TAKIGAWA Nagio 川崎医科大学, 医学部, 教授

11. A basic studyon malignant mesothelioma pathogenesis by internal radiation exposure of radium contained in the iron-containing protein Research Project

KIURA Katsuyuki 岡山大学, 岡山大学病院, 教授

12. Basic and clinical study of EGFR gene mutation-positive lung cancer using a genetically modified mouse Research Project

KIURA Katsuyuki 岡山大学, 大学病院, 教授

13. Radiofrequency ablation for pulmonary aspergilloma Research Project

HIRAKI Takao 岡山大学, 岡山大学病院, 講師

14. 上皮成長因子受容体遺伝子変異陽性肺癌の根治治療開発を目指した動物実験モデルの樹立 Research Project

木浦 勝行 岡山大学, 大学院・医歯薬学総合研究科, 准教授

15. Mechanism of progression from bronchioloalveolar carcinoma to invasive adenocarcinoma Research Project

TAKIGAWA Nagio 川崎医科大学, 医学部, 教授

16. Chemoprevention of Lung Cancer using Epidermal Growth Factor Receptor Transgenic Mice Research Project

KIURA Katsuyuki Okayama University

17. Early detection of lung cancer using aberrant promoter hypermethylation in serum DNA from patients with silicosis Research Project

TABATA Masahiro Okayama University

18. Mechanism of carcinogenesis from pulmonary atypical adenomatous hyperplasia to adenocarcinoma Research Project

TAKIGAWA Nagio Okayama University

19. Chemoprevention of second primary cancer in the patients with lung cancer Research Project

KIURA Katsuyuki Okayama University, Okayama Graduate School of Medicine, Dentistry and Pharmaceutica Sciences, Associate Professor

20. NK細胞白血病/リンパ腫の増殖機序と増殖抑制に関する研究 Research Project

原田 実根 九州大学, 大学院・医学研究院, 教授

1. persister癌細胞と腫瘍微小環境の双方を標的とした革新的腫瘍免疫療法の開発

Research Project

大橋圭明岡山大学, 大学病院, 准教授

2. Establishment of a mouse model of Oct4-positive lung cancer stem cells and development of innovative therapies to eradicate cancer stem cells

Research Project

3. Development of a curative treatment strategy for lung cancer using the persister cancer cell mouse model.

Research Project

4. Development of innovative immunotherapy for lung cancer using tumor immune-activating gene REIC

Research Project

5. Comprehensive analysis of druggable tyrosine kinase in idiopathic interstitial pneumonia

Research Project

6. Next generation lung cancer mice model for conquering cancer stem

Research Project

7. Potential influence of interleukin-6 on the therapeutic effect of gefitinib in patients with advanced non-small cell lung cancer harbouring EGFR mutations

Research Project

8. Basic study on combined modality therapy for advanced lung cancer harboring activated EGFR gene mutation

Research Project

9. Identification of stem cells from oncogenic mouse lungs by epithelial growth factor receptor gene mutation

Research Project

10. Effects of molecular-targeted drugs on nonsmoking-related lung cancer models

Research Project

11. A basic studyon malignant mesothelioma pathogenesis by internal radiation exposure of radium contained in the iron-containing protein

Research Project

12. Basic and clinical study of EGFR gene mutation-positive lung cancer using a genetically modified mouse

Research Project

13. Radiofrequency ablation for pulmonary aspergilloma

Research Project

14. 上皮成長因子受容体遺伝子変異陽性肺癌の根治治療開発を目指した動物実験モデルの樹立

Research Project

木浦勝行岡山大学, 大学院・医歯薬学総合研究科, 准教授

15. Mechanism of progression from bronchioloalveolar carcinoma to invasive adenocarcinoma

Research Project

16. Chemoprevention of Lung Cancer using Epidermal Growth Factor Receptor Transgenic Mice

Research Project

17. Early detection of lung cancer using aberrant promoter hypermethylation in serum DNA from patients with silicosis

Research Project

18. Mechanism of carcinogenesis from pulmonary atypical adenomatous hyperplasia to adenocarcinoma

Research Project

19. Chemoprevention of second primary cancer in the patients with lung cancer

Research Project

20. NK細胞白血病/リンパ腫の増殖機序と増殖抑制に関する研究

Research Project

原田実根九州大学, 大学院・医学研究院, 教授